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Is Preventing Cancer in Canines & Humans Possible?
Today, 90% of cancer clinical treatments, expenditures, and research are allocated to late-stage cancer. Unfortunately, while many extoll the adage about an ounce of prevention, trying (and failing) to treat cancer remains at the core of the battle against the disease.
There are several reasons why late-stage tumors are incredibly difficult to defeat:
By this stage, there are already billions of tumor cells.
Typically, the tumors have had years to develop an immunosuppressive environment.
And because of these, the hosts’ immune systems are often compromised at this point.
For the better part of 50 years, cancer treatment has been an uphill battle that has kept the world, the afflicted, and their loved ones on the back foot. As cancer remains one of the leading causes of death worldwide, it’s increasingly evident that we need fundamentally new approaches to finally and permanently put the prospect of cancer in our past.
Keep reading to explore a bold new approach that deconstructs cancer treatment and learn how developing a cancer vaccine for dogs may hold the key to cancer prevention.
Pouncing on Prevention
To truly have a chance at putting cancer in humanity’s rearview mirror, we must embrace new methodologies and ways of thinking. Fortunately, the work has already begun. EndCancer.org supports Calviri, a fully-integrated biotech startup in the fifth year of the world’s largest clinical trial to test a vaccine designed to prevent cancer in dogs.
And the early returns have been promising. According to Calviri Founder and CEO Stephen Johnston, cancer incidence in dogs that had an immune response to the vaccine was significantly lower than in non-vaccinated participants. The trials also surfaced unexpected results, with vaccinated dogs having markedly lower incidences of arthritis, heart disease, dementia, and other chronic diseases.
Building on the positive momentum of the trials, Calviri researchers are also investigating therapeutic vaccines for three other cancer types:
Canine Hemangiosarcoma: A highly aggressive and invasive cancer commonly found in older dogs’ spleens, hearts, livers, and skin
Human Renal Medullary Carcinoma (RMC): A rare yet aggressive type of kidney cancer
Human Neurofibromatosis: A pediatric brain cancer that causes tumors in nerve tissues
And because early diagnosis remains a critical element of Calviri’s quest to end cancer, researchers are also working on improved diagnostics for multiple types of cancers, including:
Stage 1 breast cancer
Stage 1 colorectal cancer
ICI (Immune Checkpoint Inhibitors) response and adverse events predictors for lung cancer
Calviri has imposed itself at the center of cancer research, marrying the interconnected elements of prevention, diagnosis, and treatment to develop a vaccine that could potentially end all cancer-related suffering forever. And when that day comes, we’ll have our four-legged friends to thank.
Over 800 dogs and their willing pet parents volunteered to be part of the Vaccine Against Canine Cancer Study (VACCS). After five years of testing, the experimental vaccine has shown no adverse effects.
EndCancer.org is looking for petition volunteers to advocate USDA approval for the first and only vaccine preventing cancer in dogs. By getting involved, you’re helping shape a future where cancer is no longer a formidable threat to our beloved pets.
Scientists have been able to eradicate dozens of debilitating diseases over the years through research and innovation. It’s only a matter of time before the same thing happens to cancer.